Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 Biomarker BEFREE Thus, the expression and phosphorylation levels of KU70, ILF2, CHK1 and CHK2 were examined by immunohistochemistry in 42 cases of gastric cancer. 29328366

2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 GeneticVariation BEFREE These results suggested that there was a correlation between mutation of the CHEK2 gene and gastric cancer, and provided an experimental basis for antitumor drug investigation and development according to its mutation target. 29067458

2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 Biomarker BEFREE Results of the overexpression and knockdown studies, showed that Chk1 but not Chk2 regulated the DADS-induced G2/M arrest of MGC803 cells. 25176258

2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 GeneticVariation BEFREE CHEK2 mutations predispose to gastric cancer, in particular to young-onset cases. 23296741

2013
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 Biomarker BEFREE The most significant gene in ESCC was CHEK2 (P = 2.00 × 10(-6)) and in GC was CLK2 (P = 3.02 × 10(-4)). 23504502

2013
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.460 GeneticVariation BEFREE Thus, it was indicated that germline CHK2 mutations do not contribute to the familial clustering of gastric cancer. 11011113

2000