|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Importantly, subcutaneous immunization of C57BL/6J mice with DCs ex vivo transfected with an electrostatic complex of AuNPs-SL & melanoma antigen (MART1) encoded DNA vaccine (p-CMV-MART1) induced a long lasting (100 days) anti-tumor immune response in immunized mice upon subsequent challenge with a lethal dose of melanoma.
|
30964937 |
2019 |
|
LINC00328
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.
|
27563821 |
2016 |
|
LINC00328
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
Expression of Melanoma AntiGen Encoding (MAGE) genes, particularly MAGE-A3, has been correlated with aggressive clinical course, the acquisition of resistance to chemotherapy and poor clinical outcomes of melanoma and other malignancies.
|
25107531 |
2014 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Melanoma antigen recognized by T-cells (MART-1) has been studied extensively as a clinically important diagnostic marker for melanoma, however, its biological function remains unclear.
|
23877836 |
2013 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Melanoma antigen gene family (MAGE)-A4, a member of the cancer testis antigen family, has been reported in various cancers including melanoma, bladder, head and neck, oral, and lung, and is a potential target for T-cell-receptor-based immunotherapy.
|
24238058 |
2013 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Importantly, the human melanoma cell line EST049 demonstrated reduced HER2 and melanoma antigen-specific recognition by CTLs upon HER2 transfection.
|
20715101 |
2011 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Functional CD8+ T cells against several human tumor antigens were induced, and those against the Melan-A melanoma antigen used similar TCRs to those that have been detected in T cell clones from individuals with autoimmune vitiligo or melanoma.
|
20693993 |
2010 |
|
LINC00328
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
However, the addition of ABT-737 to either a vaccine strategy involving priming with TRP-2 melanoma antigen peptide-pulsed DC and boosting with recombinant Listeria monocytogenes expressing the same melanoma antigen, or the adoptive transfer of TCR transgenic cells, did not result in superior antitumor activity against B16 murine melanoma.
|
18807035 |
2009 |
|
LINC00328
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
BCG vaccine, vaccinia vaccine and certain pathogens that were shown in previous studies to protect against melanoma have antigenic determinants homologous in their amino acids sequence with the melanoma antigen HERV-K-MEL, encoded by a human endogenous retrovirus K (HERV-K), which is expressed in about 95% of malignant melanocytes.
|
19010368 |
2009 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
In view of this, we performed an extensive cytogenetic analysis of hTERT-transduced MART-1 (melanoma antigen recognized by T cell 1)-and human papillomavirus type 16 (HPV16) E7-specific human CD8+ cytotoxic T lymphocytes (CTLs), reactive against melanoma and cervical carcinoma, respectively.
|
16002425 |
2005 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Melanoma antigen recognized by T cell 1 (MART-1) is regarded as a candidate peptide for vaccination against malignant melanoma, and it is of importance to develop strategies to improve the vaccine-elicited T-cell activation towards MART-1.
|
14871300 |
2004 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Melanoma antigen-encoding gene (MAGE-1) has been introduced as a sensitive immunohistochemical marker to aid in the diagnosis of malignant melanomas, in particular, those that are HMB-45 negative.
|
15223957 |
2004 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
We present a method to quantify mRNA coding for the melanoma-specific melanoma antigen recognized by T cells #1 (MART-1) in RNA isolated from peripheral blood.
|
11106324 |
2000 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Major histocompatibility complex class I restricted cytotoxic T cells specific for natural melanoma peptides recognize unidentified shared melanoma antigen(s).
|
10344730 |
1999 |
|
LINC00328
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
The expression of MAGE genes has been reported not only in melanoma but also in various other malignant tumors.
|
10568832 |
1999 |
|
LINC00328
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
Melanoma antigen-encoding gene expression in melanocytic naevi and cutaneous malignant melanomas.
|
10215777 |
1999 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Induction of melanoma antigen-specific cytotoxic T lymphocytes in vitro by stimulation with B7-expressing human melanoma cell lines.
|
9551360 |
1998 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Furthermore, there were no conserved amino acids in the CDR3 regions of these TcRs, indicating that multiple TcR clonotypes could mediate recognition of a single unique major histocompatibility (MHC) complex class II restricted melanoma antigen or that multiple MHC class II restricted melanoma antigens are expressed by the melanoma.
|
9789197 |
1998 |
|
LINC00328
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
The two melanoma lines also maintained susceptibility to lysis by lymphokine-activated killer (LAK) cells and by a HLA-A2-restricted melanoma-specific cytotoxic T lymphocyte (CTL) clone recognizing the melanoma antigen (Melan-A).
|
7833372 |
1994 |
|
LINC00328
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
MAGE-1 is not likely to be the common melanoma antigen recognized by the other HLA-A1- or HLA-A2-restricted cytotoxic T-lymphocytes examined in this study, but the fact that it is expressed in about 50% of melanoma cell lines makes it a reasonable target for the immunotherapy of patients bearing HLA-A1.
|
8416750 |
1993 |