Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5210
Gene Symbol: PFKFB4
PFKFB4
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression BEFREE In IDH-wildtype glioblastomas exhibiting loss of heterozygosity (LOH) of the PFKFB3 gene locus, the decrease of PFKFB3 mRNA levels was accompanied by lower PFKFB4 mRNA levels, but the PFKFB3 to PFKFB4 mRNA ratio did not differ between tumors with or without PFKFB3 LOH. 31369092

2019
Entrez Id: 5210
Gene Symbol: PFKFB4
PFKFB4
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression BEFREE In addition, we found that CD44ICD and PFKFB4 expressions are generally up-regulated in the tumor portion of breast cancer patient samples. 30613295

2018
Entrez Id: 5210
Gene Symbol: PFKFB4
PFKFB4
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression BEFREE The bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 (PFKFB4) is highly expressed in many types of cancer and its requirement for tumor survival has been demonstrated in glioma, lung, and prostate cancers. 30415245

2018
Entrez Id: 5210
Gene Symbol: PFKFB4
PFKFB4
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker BEFREE Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor. 26221874

2015
Entrez Id: 5210
Gene Symbol: PFKFB4
PFKFB4
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker BEFREE Depletion of PFKFB4 inhibited tumor growth in a xenograft model, indicating that it is required under physiologic nutrient levels. 22576210

2012