Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2731
Gene Symbol: GLDC
GLDC
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.040 GeneticVariation BEFREE Possibly damaging variants were observed in SCZ: A203V, S801N in GLDC, near the atypical nonketotic hyperglycinemia causative mutations (A202V, A802V); G825D in GLDC, a potential neural tube defect causative mutation; and R253X in AMT. 29232014

2018
Entrez Id: 2731
Gene Symbol: GLDC
GLDC
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.040 Biomarker BEFREE Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc)-deficient embryos. 29141214

2017
Entrez Id: 2731
Gene Symbol: GLDC
GLDC
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.040 Biomarker BEFREE Using HFUS, we imaged embryos carrying loss of function alleles of Gldc encoding glycine decarboxylase, a component of the glycine cleavage system in mitochondrial folate metabolism, which is known to be associated with cranial NTDs and NKH in humans. 28056489

2017
Entrez Id: 2731
Gene Symbol: GLDC
GLDC
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.040 Biomarker BEFREE To investigate this possibility, we sequenced the coding regions of the GCS genes: AMT, GCSH and GLDC in NTD patients and controls. 22171071

2012