Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker BEFREE Importantly, intervening with CXCL12/CXCR4 presents an effective therapeutic approach to treat the neuropathic pain. 30955244

2019
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker BEFREE High mobility group box 1 protein (HMGB1) and Chemokine CXC receptor 4 (CXCR4) participate in neuropathic pain development. 30142543

2018
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker BEFREE Overexpression of miR-23a by intrathecal injection of miR-23a mimics or lentivirus reduced spinal CXCR4 and prevented pSNL-induced neuropathic pain. 29386025

2018
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker BEFREE CXCR4 antagonist can elicit analgesic effects and restore the inhibitory neurotransmission such as GlyRα3 against NP. 28919816

2017
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker BEFREE (1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1.8 (A-803467), CXCR4 (AMD3100), mTOR (rapamycin), and histone deacetylase (MGCD0103); (3) combined use of systemic gabapentin and IVF ozone produced a synergistic analgesic effect in rats with neuropathic pain. 28727712

2017