Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Finally, by using knockout mice, we demonstrated that TLR2 and IFN type I play crucial roles in modulating the early neuroinflammatory response and clinical outcome of PRV infection in mice. 31675371

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Ruxolitinib was well tolerated and superior to best available therapy (including interferon [IFN]) in controlling hematocrit without phlebotomy eligibility, normalizing blood counts, and improving polycythemia vera-related symptoms in the Study of Efficacy and Safety in Polycythemia Vera Subjects Who Are Resistant to or Intolerant of Hydroxyurea: JAK Inhibitor INC424 (INCB018424) Tablets Versus Best Available Care (RESPONSE) studies. 29396713

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Meanwhile, IFN did not observe the severe hematological adverse events in patients with PV or ET. 25069759

2014

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE These results provide a rationale for the use of combinations of low doses of RG7112 and Peg-IFNα 2a for the treatment of PV or PMF patients with the intent of altering their natural history. 24869939

2014

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE To permit the long-term use of IFN, we propose combining low doses of IFN with Nutlin-3, an antagonist of MDM2, which is also capable of promoting PV CD34(+) cell apoptosis. 22872685

2012

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE We observed that alpha/beta interferon (IFN-α/β) production in response to PV infection occurred in an MDA5-dependent but RIG-I-independent manner in primary cultured kidney cells in vitro. 22072781

2012

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE In this study, we present evidence that the TLR3/TICAM-1 pathway governs IFN induction and host protection against PV infection. 21998457

2011

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 GeneticVariation BEFREE This article highlights the current status of IFN-?2 in the treatment of patients with ET, PV, primary myelofibrosis and myelofibrosis following ET and PV. 22077528

2011

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.100 Biomarker BEFREE Interferon alpha (alpha-IFN) is increasingly used for the treatment of patients affected by polycythemia vera (PV). 8018766

1994