Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.330 AlteredExpression BEFREE OPN is upregulated in the lungs of patients with pulmonary hypertension (PH) associated with pulmonary fibrosis, suggesting that the lung is a source of OPN. 30963672

2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.330 Biomarker BEFREE Comparison between WT and Opn KO mice revealed that OPN critically regulated MWCNT-induced lung fibrosis as indicated by reduced fibrotic focus formation and myofibroblast accumulation in Opn KO lungs. 28595626

2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.330 Biomarker BEFREE The matrix metalloproteinase-7 (MMP-7) and osteopontin (OPN) are both multifunctional proteins with roles in inflammation, cell proliferation, tissue remodeling and so on, implicated in the pathogenesis of numerous conditions including pulmonary fibrosis. 26330178

2015