Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential 		0.020 GeneticVariation BEFREE Therefore, we performed an investigator-initiated phase 1 trial of the oral MDM2 antagonist idasanutlin (RG7388; Roche) in patients with high-risk PV/ET for whom at least 1 prior therapy had failed. 31167802

2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential 		0.020 Biomarker BEFREE Samples of PV and ET analyzed in chronic phase disease were consistently devoid of all genetic lesions tested, suggesting that alterations of TP53, NRAS, KRAS, and MDM2 do not contribute significantly to development of chronic phase PV and ET. 9258660

1997