Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0158570
Disease: Vascular anomaly
Vascular anomaly 		0.050 GeneticVariation BEFREE R849W Tie2 is the most common mutation implicated in an inherited form of vascular malformations and has been shown to be activating, though little is known about the kinetic features of catalysis. 30638931

2019
Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0158570
Disease: Vascular anomaly
Vascular anomaly 		0.050 GeneticVariation BEFREE Soblet et al. describe cis mutations in TEK/Tie-2 in blue rubber bleb nevus and sporadic vascular malformations. 28010758

2017
Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0158570
Disease: Vascular anomaly
Vascular anomaly 		0.050 AlteredExpression BEFREE In addition, we showed that Tie2 mRNA expression in spinal VMs was similar to soft tissue VMs, but obviously lower than infant hemangiomas (P<0.01). 26115772

2015
Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0158570
Disease: Vascular anomaly
Vascular anomaly 		0.050 GeneticVariation BEFREE Our results identified two novel Tie2 gene polymorphisms with genetic susceptibility to VMs, although future functional validation of the two polymorphisms is warranted in the future. 23566851

2013
Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0158570
Disease: Vascular anomaly
Vascular anomaly 		0.050 GeneticVariation BEFREE Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. 21962923

2011