DisGeNET - a database of gene-disease associations

Source: BEFREE

Disease: Lung Diseases, Interstitial ×

Gene: IL18 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	3606
Gene Symbol:	IL18

IL18

CUI:	C0206062
Disease:	Lung Diseases, Interstitial

Lung Diseases, Interstitial

0.230

Biomarker

BEFREE

Diagnostic values of IL-18 for the presence of ILD were investigated using receiver operating characteristics curve analysis.

30269670

2019

Entrez Id:	3606
Gene Symbol:	IL18

IL18

CUI:	C0206062
Disease:	Lung Diseases, Interstitial

Lung Diseases, Interstitial

0.230

Biomarker

BEFREE

The injection of IL-18 plus IL-2 (IL-18/IL-2) into C57BL6 (B6) mice induced acute ILD that resembled early-stage human ILD.

21257923

2011

Entrez Id:	3606
Gene Symbol:	IL18

IL18

CUI:	C0206062
Disease:	Lung Diseases, Interstitial

Lung Diseases, Interstitial

0.230

Biomarker

BEFREE

The findings suggest that TGF-beta signalling may play an important role in the pathogenesis of IL-18 plus IL-2-induced ILD in mice.

20089076

2010