Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma 		0.350 Biomarker BEFREE Moreover, ICI-118,551 also impaired the nuclear internalization of HIF-1α in Hemangioblastomas and hypoxic primary endothelial cells, reducing significantly the activation of HIF-target genes and halting the tumour-related angiogenic processes. 31296894

2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma 		0.350 AlteredExpression BEFREE The VHL-HIF-1 regulated genes VEGF and CAIX are expressed in hemangioblastomas but significant HIG-2 expression is not observed. 25310734

2014
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma 		0.350 AlteredExpression BEFREE Whereas the development of hemangioblastomas and renal cell carcinomas has been attributed to impaired HIF-1/2alpha down-regulation by pVHL mutant proteins, the molecular defects underlying the development of pheochromocytomas are still unknown. 19228690

2009
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma 		0.350 Biomarker BEFREE HIF-1alpha was detected in tumor cell nuclei of both hemangioblastomas and CC-RCCs. 16024619

2005
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma 		0.350 AlteredExpression BEFREE Moreover, immunohistochemical analyses of RCCs and hemangioblastomas demonstrate up-regulation of HIF-1alpha and HIF-2alpha in the tumor cells. 11114720

2000