Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE Moreover, overexpression of miR-16 also impaired cell viability, migration, invasion and abundances of MMP-9 and MMP-2 in oral cancer cells. 30639311

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE Therefore, we examined the effect of HBP1 on the activation of the MMP members, MMP-2, -9, and -13 that are highly associated with the aggressiveness of oral cancer. 30191992

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE Erratum: Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells. 31458539

2018

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 GeneticVariation BEFREE The allelic frequency distributions showed that the variant T allele of MMP2 promoter 1306 conferred lower oral cancer susceptibility than the wild-type C allele (odds ratio=0.61, 95% confidence interval=0.50-0.75, p=1.1E-6). 30504396

2018

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 AlteredExpression BEFREE In conclusion, we found that EPE could inhibit oral cancer metastasis through the inhibition of MMP-2 expression. 29962088

2018

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells. 30023811

2018

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer? 27853937

2017

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 GeneticVariation BEFREE Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer. 28595731

2017

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 AlteredExpression BEFREE Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. 26036622

2015

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.200 Biomarker BEFREE Activation of TLR-9 signaling could promote human oral cancer HB cells invasion with the induction of MMP-2 presentation by attenuating AP-1 binding activity, suggesting a novel anti-metastatic application for TLR-9 targeted therapy in oral cancer in the future. 24658023

2014

Entrez Id: 26057
Gene Symbol: ANKRD17
ANKRD17
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.110 Biomarker BEFREE Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer. 28580594

2017

Entrez Id: 152330
Gene Symbol: CNTN4
CNTN4
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.110 GeneticVariation BEFREE Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer. 28595731

2017

Entrez Id: 6641
Gene Symbol: SNTB1
SNTB1
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.110 GeneticVariation BEFREE Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer. 28595731

2017

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2. 31823521

2020

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE The current study was designed to elucidate the regulatory mechanism between HDGF and vascular endothelial growth factor (VEGF) and the clinical impact of oral cancer. 31711427

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 AlteredExpression BEFREE It should be considered in the studies that the pathological changes at the early stages of the relationship between DM and oral cancer may be related to p16 expression; however, it may also be linked with p16-related aging process. 31687322

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Targeted disruption of PI3K/Akt/mTOR signaling pathway, via PI3K inhibitors, promotes growth inhibitory effects in oral cancer cells. 30519710

2019