Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 Biomarker BEFREE CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer. 30276551

2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 AlteredExpression BEFREE Ectopic expression of ERBB2/ERBB3 mutants upregulated PD-L1 expression in GBC cells, effectively suppressed normal T-cell-mediated cytotoxicity in vitro through activation of the PI3K/Akt signalling pathway and contributed to the growth and progression of GBC in vivo. 29954840

2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 Biomarker BEFREE DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway by targeting PTEN. 31411121

2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 Biomarker BEFREE Consistent with STYK1 gene knockdown, AKT specific inhibitor MK2206 abrogated tumor promoting action induced by STYK1, suggesting that PI3K/AKT pathway is essential for the oncogenic role of STYK1 in GBC. 29413947

2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 Biomarker BEFREE In conclusion, miR-143-3p suppresses tumour angiogenesis and growth of GBC through the ITGA6/PI3K/AKT/PLGF pathways and may be a novel molecular therapeutic target for GBC. 29416013

2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 Biomarker BEFREE Taken together, these findings indicate that DSN induces GBC apoptosis through inhibiting ROS-mediated PI3K/AKT signalling. 28656003

2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 AlteredExpression BEFREE The depletion of BRD4 in GBC cell lines resulted in obvious cell apoptosis and downregulated the expression levels of Bcl-2, p-PI3K and p-AKT. 28766687

2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 GeneticVariation BEFREE PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. 27317099

2016
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 GeneticVariation BEFREE Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC. 26947513

2016
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.100 AlteredExpression BEFREE We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 in GBC. 25623055

2015