×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
<b>Methods:</b> Starting from the BXPC3 cell line, we generated and profiled a TRAIL -resistant model of pancreatic cancer , testing the impact of the combined treatment <i>in vitro</i> with specific cytotoxicity and metabolic assays.
30809285 2019
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Together, the results indicate that CQ in combination with TRAIL may be useful to treat human pancreatic cancer .
29513749 2018
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
New path to treating pancreatic cancer : TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment.
30075209 2018
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines.
29867042 2018
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
AlteredExpression
BEFREE
We observed that TRAIL -resistant pancreatic cancer cells had higher levels of HOTAIR expression, whereas TRAIL -sensitive pancreatic cancer cells had lower HOTAIR levels.
28476883 2017
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
AlteredExpression
BEFREE
HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression.
28476028 2017
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer .
28188806 2017
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
LPS promotes resistance to TRAIL -induced apoptosis in pancreatic cancer .
28572836 2017
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
The TRAIL mice displayed significantly decreased tumor volumes and an enhanced overall survival in pancreatic cancer .
26390425 2016
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
We found that the novel CTL harboring Lenti/hCD40L/E1AB and Ad5/35-TRAIL inhibited pancreatic cancer cell growth and angiogenesis in vitro and in vivo.
27876704 2016
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
AlteredExpression
BEFREE
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment.
26677013 2016
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Our studies support the use of these readily available CaM antagonists combined with TRAIL -activating agents for pancreatic cancer therapy.
26320171 2015
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Restoration of TRAIL -induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11.
25684663 2015
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
TRAIL treatment increased ROS in two TRAIL -sensitive pancreatic cancer cell lines, MiaPaCa-2 and BxPC-3, but ROS were involved in TRAIL-induced apoptosis only in MiaPaCa-2 cells.
26000607 2015
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
TRAIL -receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill.26138346 2015
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer .
25482930 2014
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy.
23833311 2013
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Targeted inhibition of OPG binding to TRAIL may represent a therapeutic approach in the treatment of pancreatic cancer .
23219833 2013
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Our results indicate that MUC5AC inhibits TRAIL ‑induced apoptosis in human pancreatic cancer and may serve as an important indicator in diagnosis and prognosis.
23292004 2013
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Reduction of decoy receptor 3 enhances TRAIL -mediated apoptosis in pancreatic cancer .
24204567 2013
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Here, we report that DHA enhances the efficacy of Apo2L /TRAIL for the treatment of pancreatic cancer .
22666346 2012
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
Combined treatment with oncolytic adenovirus-mediated hSSTr2 and TRAIL gene provides the rationale for a clinical trial in pancreatic cancer .
19671855 2009
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
Biomarker
BEFREE
The present study explored the possibility of sensitizing pancreatic cancer to gemcitabine chemotherapy by combining the chemotherapy with the proapoptotic genes Bax and TNF-related apoptosis-inducing ligand (TRAIL ).
17984977 2008
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
AlteredExpression
BEFREE
TRAIL can stimulate the expression of uPA, IL-8, MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt.18397859 2008
×
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
Pancreatic carcinoma
0.100
AlteredExpression
BEFREE
Thus, our findings for the first time indicate that targeting XIAP represents a promising strategy to enhance the antitumor activity of TRAIL in pancreatic cancer , which has important clinical implications.
16832350 2007