Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP. 29574070

2019

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE CKD-519, a potent cholesteryl ester transfer protein (CETP) inhibitor, is a clinical candidate being developed for the treatment of dyslipidemia. 30107219

2018

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 AlteredExpression BEFREE Conversely, Golden Syrian hamsters have a lipoprotein metabolism mimicking human dyslipidemia since it does express the cholesteryl ester transfer protein (CETP). 29155143

2018

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of mixed dyslipidemia. 28884824

2018

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Dietary fat intake and genetic factors including CETP Taq1B polymorphism could also affect lipid profile concentrations, in particular HDL-c. We decided to study the frequency of this polymorphism and its interaction with dietary fat intake on HDL-c concentration among Iranian T2DM patients with and without dyslipidemia. 28065481

2018

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Anacetrapib is a cholesteryl ester transfer protein inhibitor intended for the treatment of dyslipidemia. 30029292

2018

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE We aimed to assess the effects of cholesteryl ester transfer protein inhibitor anacetrapib added to statin ± other lipid-modifying therapies (LMT) in Japanese patients with dyslipidemia who were not at their LDL-C goal. 28478132

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE In this review, we focus on dyslipidemia drug targets traceable to human genetic studies, including statins and ezetimibe, as well as promising new classes such as inhibitors of proprotein convertase subtilisin kexin 9, apolipoprotein B, microsomal triglyceride transfer protein, cholesteryl ester transfer protein, angiopoietin-like proteins types 3 and 4 and apolipoprotein C-III. 28109622

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Cholesteryl ester transfer protein (CETP) inhibitors are a new class of therapeutics for dyslipidemia that simultaneously improve two major cardiovascular disease (CVD) risk factors: elevated low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol. 28911944

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Anacetrapib is a potent and selective CETP inhibitor and is undergoing phase III clinical trials for the treatment of dyslipidemia. 27432781

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Evacetrapib: Another CETP Inhibitor for Dyslipidemia With No Clinical Benefit. 28099220

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Additional safety evaluation (no blood pressure elevation in guinea pigs) and pharmacokinetics studies indicated that the potential druggability for compound 20 which is a promising lead for development of a new class of CETP inhibitors for the treatment of dyslipidemia. 28802120

2017

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE The polymorphism of CETP genes rs708272, rs3764261, rs1800775, rs711752, rs12149545 was closely related to the dyslipidemia in the Xinjiang Uyghur and Kazakh ethnic groups; and the rs708272 T, rs3764261 T, rs711752 A, and rs12149545 A alleles could reduce risk of dyslipidemia in the Uyghur and Kazakh populations, however, the rs1800775 C allele showed risk factors. 26694435

2015

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 PosttranslationalModification BEFREE CETP and LPL DNA methylation levels are associated with blood lipid profile, suggesting that further studies of epipolymorphisms should most certainly contribute to a better understanding of the molecular bases of dyslipidemia. 23623643

2013

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Inhibition of CETP may reduce the risk of atherosclerosis in patients with dyslipidemia. 21122682

2011

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Inhibition of CETP is considered a potential approach to treat dyslipidemia. 20556633

2010

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein. 19147676

2009

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE The contribution to dyslipidemia of 20 selected single nucleotide polymorphisms of 13 genes reported in the literature to be associated with plasma lipid levels (ABCA1, ADRB2, APOA5, APOC3, APOE, CETP, LIPC, LIPG, LPL, MDR1, MTP, SCARB1, and TNF) was assessed by longitudinally modeling more than 4400 plasma lipid determinations in 438 antiretroviral therapy-treated participants during a median period of 4.8 years. 17700364

2007

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE This article reviews the physiology of CETP in lipoprotein metabolism and the data in animals and humans that are relevant to the question of whether CETP inhibition may some day be part of the clinical armamentarium for treating dyslipidemia and atherosclerotic vascular disease. 15296707

2004

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Single nucleotide polymorphisms (SNPs) and haplotypes in the CETP gene were determined in 98 patients with untreated dyslipidemias and analyzed for associations with plasma CETP and plasma lipids before and during statin treatment. 14583798

2003

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE CETP is often involved in secondary dyslipidemia and is susceptible to modify the composition of plasma lipoproteins in an atherogenic way. 8964591

1996