×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
Here, we focused on serum osteopontin (OPN ), a pleiotropic protein overexpressed in lung cancer and involved in the immune response.
31376097 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Moreover, the effect of Oct4-Egr1-OPN axis on lung cancer progression was evaluated by cell migration assay and mice study.
31399076 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
The current study sought to investigate the clinical implications of OPN expression in NSCLC and the role of OPN in the aggressiveness of the lung cancer cells.
31792339 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Our results suggest that SPP1 enhanced the second-generation EGFR TKI resistance in lung cancer , and inhibiting SPP1 might be a therapeutic target to overcome afatinib resistance.
30832751 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
Through analysis of GSE19804,the heat map showed SPP1 was the highest expressed in tumor tissues. qRT-PCR and western-blot detected SPP1 expression in lung cancer tissues was higher than that in normal adjacent tissues and was significantly increased in lung cancer cell lines.
30387012 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
Combined low expression of FSTL1 and high expression of SPP1 predicted a poorer prognosis for patients with lung cancer .
31653686 2019
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
OPN levels ≥35 ng/mL could predict the presence of LC among COPD patients.29607144 2018
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
Furthermore, there was markedly increased expression of HIF-1α and plasma OPN levels in FaDu and EC109 xenografts compared with A549 .
29616117 2018
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells.29254164 2017
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
OPN -a may represent a bone metastatic factor in human lung cancer , as well as a potential therapy target.28476789 2017
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
These results highlight the importance of SPP1 in mediating macrophage polarization and lung cancer evasion, suggesting a potential therapeutic target for lung cancer .
28830685 2017
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Role of osteopontin in lung cancer evolution and heterogeneity.
27578008 2017
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA.
26141346 2015
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Research has shown that secreted phosphoprotein-1 (SPP1 ) is essential in MPE associated with lung cancer .
24758329 2014
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Gene array and bioinformatics analyses implied that osteopontin , LAMB3 and ITGB1 were key genes involved in lung cancer .
23441154 2013
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
GeneticVariation
BEFREE
This study examined whether genetic variations in the osteopontin gene are associated with survival of lung cancer patients and occurrence rate of bone metastasis.
23883434 2013
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Influence of osteopontin silencing on survival and migration of lung cancer cells.
23161119 2013
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Thus, results of the present study suggested that targeting OPN by introducing OPN TM may be a good strategy for treating lung cancer .
24008322 2013
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
GeneticVariation
BEFREE
Identification and quantification of osteopontin splice variants in the plasma of lung cancer patients using immunoaffinity capture and targeted mass spectrometry.
22188260 2012
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Interestingly, we showed that knockdown of OPN by lentivirus-mediated shRNA induced the autophagy of human lung cancer cell.
22481206 2012
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
AlteredExpression
BEFREE
We observed positive correlation of OPN and AhR expression in lung cancer specimen.
22037483 2012
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
Our data suggested that OPN served as a potential biomarker for invasive lung cancer and provided new molecular-targeted therapy for lung cancer based on lentivirus-mediated RNA interference.
21207061 2011
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
However, the role of OPN in chemo-sensitivity of human lung cancer has not yet been elucidated.
19285749 2009
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
In this study, we developed a stable OPN transfectant from human lung cancer cell line SBC-3 which does not express the intrinsic OPN mRNA.
17482311 2007
×
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
Malignant neoplasm of lung
0.400
Biomarker
BEFREE
The present study evaluated the clinical and biological importance of osteopontin in human lung cancer .
16000556 2005