Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 AlteredExpression BEFREE Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer. 28952211

2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. 31801250

2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE This strategy may overcome the disadvantages of naked Ad5-PTEN and enhance the antitumor effect on liver cancer. 29467932

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE PTEN gene has guiding significance in predicting the occurrence, development and prognosis of liver cancer. 30405802

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 AlteredExpression BEFREE HULC is negatively associated with expression of PTEN or miR15a in patients of human liver cancer. 29895332

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Ablation of PTEN or Hippo pathway components induces liver cancer in a murine model by hyperactive AKT or YAP/TAZ, respectively. 29699606

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Here, we have shown that deletion of both PTEN and SAV1 in the liver accelerates the development of NAFLD and liver cancer in mice. 29400692

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Total Flavonoids from <i>Oroxylum indicum</i> Induce Apoptosis via PI3K/Akt/PTEN Signaling Pathway in Liver Cancer. 29636773

2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE A recombinant adenovirus carrying the tumor suppressor gene PTEN (Ad5-PTEN) is an effective antitumor agent against liver cancer. 28522194

2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and provide new insight into the treatment of this disease. 27173355

2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE SHP2 and PTEN deficiencies were detected in liver cancer patients with poor prognosis. 27974211

2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Herein, we demonstrate excessive CUDR cooperates with excessive CyclinD1 or PTEN depletion to accelerate liver cancer stem cells growth and liver stem cell malignant transformation in vitro and in vivo. 26513297

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 AlteredExpression BEFREE Besides, miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay, and the expression level of miR-32 could affect the proliferation, migration, and invasion of liver cancer cell lines via PTEN/Akt signaling pathway. 25647261

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 GeneticVariation BEFREE Association of PTEN gene polymorphisms with liver cancer risk. 26823866

2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker BEFREE Mutation or deletion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is strongly correlated with human liver cancer. 24027047

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 GeneticVariation BEFREE Phosphatase and tensin homolog (PTEN) is a tumor-suppressor gene that is mutated in cancer of the liver, pancreas, endometrium, and prostate. 19082655

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 AlteredExpression BEFREE Recently, we have found that HBx causes the progression of liver cancer through down-expression of PTEN, known as a tumor suppressor gene (1). 15132991

2004