Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 AlteredExpression BEFREE Although the predominant phenotype of the MYB-NFIB GEMM was B-cell leukemia, we also generated a MYB-activated ACC-like mammary tumor cell line. 31606723

2019
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 GeneticVariation BEFREE We also analyzed ACC-specific MYB and MYBL1 gene rearrangements by fluorescence in situ hybridization (FISH). 29496310

2018
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 GeneticVariation BEFREE It is concluded that MYBL1 alterations are detected in primary cutaneous ACC but are apparently less common compared with MYB and NFIB alterations. 29570128

2018
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 GeneticVariation BEFREE The t(6;9) (q22-23;p23-24) translocation, resulting in a MYB-NFIB gene fusion has been found in ACCs from the salivary glands and other organs. 27859477

2017
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 AlteredExpression BEFREE The majority of ACCs express the oncogenic transcription factor MYB (also c-myb), often in the context of a MYB gene rearrangement. 27566443

2016
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 AlteredExpression BEFREE Interestingly, tumors with MYB and MYBL1 translocations displayed similar gene expression profiles, and the combined MYB and MYBL1 expression correlated with outcome, suggesting that the related MYB proteins are interchangeable oncogenic drivers in ACC. 26631070

2016
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 AlteredExpression BEFREE Reciprocal MYB and MYBL1 expression was consistently found in ACCs. 26631609

2016
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 GeneticVariation BEFREE A significant portion of adenoid cystic carcinoma (ACC) cases are characterized by a t(6;9)(q22-23;p23-24) translocation that originates a MYB-NFIB fusion oncogene. 26309189

2015
Entrez Id: 4603
Gene Symbol: MYBL1
MYBL1
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.090 GeneticVariation BEFREE Many ACCs have a t(6;9) chromosomal translocation resulting in a MYB-NFIB fusion gene, but the clinical significance is unclear. 25963073

2015