×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
These findings indicate that BCA exerts its cytotoxic effects by promoting phosphorylation/ubiquitin-dependent degradation of β-catenin and may potentially serve as a chemopreventive agent for colonrectal and liver cancers .
31163223 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin .
31322782 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway.
30359743 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway.
30981110 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
In conclusion, this study revealed that the reciprocal regulation between O-GlcNAcylation and β-catenin facilitated the proliferation of liver cancer .
30762425 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
AlteredExpression
BEFREE
Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways.
30418535 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Using data from The Cancer Genome Atlas, from the LIRI-JP (Liver Cancer - RIKEN, JP project), and from our transcriptomic, transfection and mouse transgenic experiments, we identify a GRN which functionally links LIN28B-dependent dedifferentiation with dysfunction of β-catenin (CTNNB1 ).
30953666 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
GeneticVariation
BEFREE
Mutations in <i>CTNNB1</i>, the gene encoding β-catenin , are common in colon and liver cancers , the most frequent mutation affecting Ser-45 in β-catenin .
31690625 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin .
29555987 2018
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Significantly, we also found that excessive β-catenin abrogated the effect of MEG3 in liver cancer .
29449541 2018
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Mefloquine targets β-catenin pathway and thus can play a role in the treatment of liver cancer .
29578061 2018
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin -Driven Hepatocellular Cancer .
28807594 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Let7b modulates the Wnt/β-catenin pathway in liver cancer cells via downregulated Frizzled4.
28671046 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
GeneticVariation
BEFREE
The liver cancer -specific signature 16, associated with alcohol, displays a unique feature of transcription-coupled damage and is the main source of CTNNB1 mutations.
29101368 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Collectively, we conclude that suppression of both Sirt1 and Wnt/βCatenin might be effective in treating liver cancer .
28583374 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Knockout of ASIC1a by CRISPR/CAS9 inhibited liver cancer cell proliferation and tumorigenicity in vitro and in vivo through β-catenin degradation and LEF-TCF inactivation.
27462920 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation.
29383099 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.
28671671 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice.
27981621 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
We studied T-UCRs downstream of the Wnt/β-catenin pathway in liver cancer .
27618837 2017
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
GeneticVariation
BEFREE
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin -mutations.
25792709 2016
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
AlteredExpression
BEFREE
Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma.26942873 2016
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
Biomarker
BEFREE
We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance.
26811628 2016
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
GeneticVariation
BEFREE
These results suggest that most colorectal and liver cancers with mutations in components of the β-catenin degradation complex do not strongly rely on extracellular Wnt ligand exposure to support optimal growth.
27851986 2016
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Malignant neoplasm of liver
0.400
AlteredExpression
BEFREE
Furthermore, using TOPflash and reverse transcription‑quantitative polymerase chain reaction analysis, Wnt/β‑catenin signaling and the transcriptional regulation of Wnt/β‑catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells.
26956539 2016