Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE Our findings suggest that changes in expression of COX-2 and iNOS may be potentially useful in predicting the progression of endometrial cancer and treatment effectiveness. 31533599

2020
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE Integration of eicosanoid and gene expression data showed that the accepted paradigm of increased COX-2-mediated prostaglandin production does not apply in EC carcinogenesis. 30168128

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE COX-2 was positive 19 cases (38%) of endometrial carcinoma. 30488858

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma. 29404887

2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma. 28474124

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. 26468779

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE HER-2/neu induced the improvement of autocrine estrogen in endometrial carcinoma cell through triggering the COX-2/P450arom signal. 23453006

2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE We found a positive relationship between COX-2 and MDR1 mRNA expression in endometrial cancer. 24100466

2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE Expression of cyclooxygenase-2 in uterine endometrial cancer and anti-tumor effects of a selective COX-2 inhibitor. 15809736

2005
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE It is concluded that the PI 3-K/Akt survival pathway is involved in the regulation of COX-2 and PGE2 synthesis in human endometrial cancer cells. 15067356

2004
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE COX-2 may be associated with endometrial cancer carcinogenesis during the postmenopausal period but not with tumor aggressiveness and p53 overexpression. 15342458

2004
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. 15016316

2004
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker BEFREE COX-2 positivity increased from Grade 1 (13.6%) to Grade 2 (41.7%) to Grade 3 (60.9%) endometrial carcinoma (P = 0.0049). 12209724

2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 AlteredExpression BEFREE COX-2 expression in epithelial cells was significantly greater in endometrial cancer (n = 63) and endometrial hyperplasia (n = 6) than in normal endometrium in any phase (n = 53). 11957147

2002