Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.020 AlteredExpression BEFREE These findings suggest AKT2 as a promising target for future anti-cancer therapies at three important levels: (i) Epithelial-to-mesenchymal transition (EMT) reversion and maintenance of CSC subpopulation in primary tumors, (ii) reduction of CTC and the likelihood of metastatic spread, and (iii) prevention of tumor recurrence through inhibition of CSC tumorigenic and metastatic potential. 31357505

2019
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.020 Biomarker BEFREE These results prompt AKT2 inhibition as a powerful therapeutic target against CSC and pave the way to the appearance of more effective nanomedicine-based gene therapies aimed to prevent CSC-related tumor recurrence. 29667444

2018