Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.040 AlteredExpression BEFREE Loss of p(Ser2448)-mTOR staining was significantly linked to advanced stage (p = 0.0027), high-grade (p = 0.0045), nodal positive cancers (p = 0.0483), early tumor recurrence (p < 0.0001, independently from stage and grade, p = 0.0016), lack of Ets-related gene (ERG) fusion (p < 0.0001), reduced androgen receptor expression (p < 0.0001 each) and increased cell proliferation (p = 0.0092) in all cancers and in the subset of ERG-fusion-positive cancers. 22886792

2013
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.040 AlteredExpression BEFREE This up-regulation in the AR levels is shown to increase sensitivity to low levels of androgen, leading to ligand-dependent downstream gene expression and tumor recurrence. 16210922

2005
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.040 Biomarker BEFREE A critical question is whether the androgen receptor mediates recurrent tumor growth after androgen deprivation therapy. 11389051

2001
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.040 GeneticVariation BEFREE High-level amplification of the AR gene was found in the recurrent tumor, whereas no evidence of amplification was found in the primary tumor. 9076469

1997