Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 47
Gene Symbol: ACLY
ACLY
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker BEFREE We identify a key role for the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. 30626590

2019
Entrez Id: 47
Gene Symbol: ACLY
ACLY
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 PosttranslationalModification BEFREE Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis. 31534141

2019
Entrez Id: 47
Gene Symbol: ACLY
ACLY
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 AlteredExpression BEFREE Studies have shown a role for ACLY in tumorigenesis whereby increased levels of the enzyme leads to increased metabolic activity via activation of Akt signaling. 25537655

2015
Entrez Id: 47
Gene Symbol: ACLY
ACLY
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker BEFREE Taken together, our results suggest a novel function of ACLY in cellular senescence and tumorigenesis. 25367309

2015
Entrez Id: 47
Gene Symbol: ACLY
ACLY
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker BEFREE A definitive role for ACL in tumorigenesis has emerged from ACL RNAi and chemical inhibitor studies, showing that ACL inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. 21688263

2012