Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0598608
Disease: Hyperhomocysteinemia
Hyperhomocysteinemia 		0.040 Biomarker BEFREE By using the Toll-like receptor 4 (TLR4)-specific inhibitor TAK-242 or TLR4-deficient macrophages, we found that culture supernatants from Hcy-activated B cells and HHcy plasma IgG polarized inflammatory macrophages in a TLR4-dependent manner. 31782769

2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0598608
Disease: Hyperhomocysteinemia
Hyperhomocysteinemia 		0.040 GeneticVariation BEFREE In the previous studies, we have characterized the role of TLR-4 mutation in attenuating vascular remodeling in hyperhomocysteinemia. 28386844

2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0598608
Disease: Hyperhomocysteinemia
Hyperhomocysteinemia 		0.040 Biomarker BEFREE Ablation of Toll-like receptor 4 mitigates central blood pressure response during hyperhomocysteinemia. 28665886

2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0598608
Disease: Hyperhomocysteinemia
Hyperhomocysteinemia 		0.040 Biomarker BEFREE We found that HHcy causes heart hypertrophy and promotes oxidative stress while mice with HHcy and inactivated TLR4 showed significant improvement in examined parameters. 28738166

2017