Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 471
Gene Symbol: ATIC
ATIC
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker BEFREE Here we clearly observed synergistic suppression of cell growth in all three breast cancer cell lines (MCF-7, MDA-MB-361 and HCC38) when co-treating cells with PI3K inhibitor GDC-0941 and AMPK activator AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide). 29504069

2018
Entrez Id: 471
Gene Symbol: ATIC
ATIC
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker BEFREE AICAR and MTX exerts similar additive antiproliferative effect on other breast cancer cell lines, such as SKBR and 4T1 cells, too. 26919657

2016
Entrez Id: 471
Gene Symbol: ATIC
ATIC
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker BEFREE Investigating effects of AMPK activation on breast cancer cell signaling and survival, we found that breast cancer cell lines with amplification and over-expression of HER2 or EGFR are 2- to 5-fold more sensitive to cytotoxic effects of AICAR, a canonical pharmacological activator of AMPK, than breast cancer cell lines lacking HER2 or EGFR overexpression. 26143491

2015