Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression BEFREE We found that mRNA expression levels of TLR2 but not TLR 4 and 9 are up-regulated in platelets of patients with ACS when compared to patients without coronary atherosclerosis. 31644579

2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker BEFREE TLR4, miR-155, and inflammatory cytokines may be closely related to ACS. 28407320

2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker BEFREE S100A8/A9 expression was significantly correlated with TLR-4 and COX-2 in the ACS group and with TLR-4 in the CHD group. 30367682

2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker BEFREE TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS. 25179298

2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker BEFREE Pharmacologic inhibition of TLR4 and hemopexin replacement therapy prior to hemin infusion protected sickle mice from developing ACS. 24084741

2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression BEFREE The TLR4 expression levels were significantly higher in the ACS group than in the SAP group. 19556696

2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression BEFREE We suggest that TLR4 and MAPK families maybe involved in activation of circulating DC of ACS patients. 18373609

2008