|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data suggests that HLA-DPB1 mismatching and CMV reactivation increase risk of aGVHD independently.
|
30683577 |
2019 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status.
|
29660451 |
2018 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
Our results suggest avoidance of nonpermissive GVH HLA-DPB1 mismatches for lowering the risk for grade II to IV and III to IV aGVHD.
|
29386198 |
2018 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
The risk of acute graft-versus-host disease (aGVHD) was analyzed in 1286 patients with single HLA-DPB1 mismatch UR-HCT.
|
29246901 |
2018 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
The risk of acute graft-versus-host disease (GvHD) after hematopoietic stem cell transplantation is increased with donor-recipient HLA-DPB1 allele mismatching.
|
29126928 |
2018 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
No significant effect of HLA-DPB1 mismatch was observed in the risk of acute GVHD, engraftment or mortality.
|
28652579 |
2018 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
We identified three novel susceptibility loci in the HLA-DP region of recipient genomes that were associated with III-IV acute GvHD (rs9277378, P=1.58E-09; rs9277542, P=1.548E-06 and rs9277341, P=7.718E-05).
|
27595289 |
2017 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
DPB1 mismatch increased risk of chronic graft-versus-host disease (cGVHD; RR 2.89 [1.19-9.53], P=.016) compared with DPB1-matched transplants, but there were no differences in overall mortality, risk of relapse, or acute GVHD (aGVHD).
|
28632323 |
2017 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
A significant RR of HLA allele mismatch compared with match was seen with HLA-A, -B, -C, and -DPB1 for grade III-IV acute graft-versus-host disease (GVHD), and HLA-C for chronic GVHD.
|
25519752 |
2015 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
Without assuming HLA unrestriction, we successfully captured a known association between HLA-DPB1 disparity (P = 4.50 × 10(-9)) and grade II-IV aGVHD development, providing proof of concept for the GWAS design aimed at discovering genetic disparity associated with aGVHD.
|
26432889 |
2015 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
The risk of acute GVHD among recipients whose mismatched HLA-DPB1 allele was linked to rs9277534G (high expression) was compared with the risk among recipients whose mismatched HLA-DPB1 allele was linked to rs9277534A (low expression).
|
26267621 |
2015 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
Outcome analysis revealed that TCE3 and TCE4 non-permissive HLA-DPB1 disparities were not associated with worsened overall survival, relapse risk neither risk of acute GvHD.
|
22504408 |
2012 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
The risk of acute graft-versus-host disease (GVHD) of these HLA haplotypes was assessed with multivariate Cox regression in 712 patients transplanted from HLA fully (HLA-A, B, C, DRB1, DQB1, and DPB1) matched unrelated donors.
|
20335219 |
2010 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
We identified 4 HLA-Cw and 6 HLA-DPB1 mismatch combinations responsible for a decreased risk of relapse; of these, 8 of 10 combinations were different from those responsible for severe acute GVHD, including all 6 of the HLA-DPB1 combinations.
|
18997170 |
2009 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DPB1 allele mismatches were significantly associated with an increased incidence of acute graft-versus-host disease (aGvHD) and worse overall survival (OS).
|
18544086 |
2008 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
A correlation between acute GVHD and matching for each individual DPB1 polymorphic region and for residue 69 of the DP beta molecule, which seems to be a key residue in the alloimmune response, was not observed.
|
12379888 |
2002 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
A threshold effect of multiple HLA-DP disparities is evident in determining the risk of acute GVHD after haematopoietic cell transplantation from unrelated donors.
|
11298597 |
2001 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
In order to optimise our selection procedure, we retrospectively analysed patients who developed aGVHD > or = II by means of sequencing based typing for HLA-DPB and frequency analysis of alloreactive helper and cytotoxic T lymphocyte precursors (HTLp-f and CTLp-f).
|
9877266 |
1998 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
Disparities in class II HLA alleles of the DRB1, DQA1, DQB1, DPA1, and DPB1 loci were not identified as significant risk factors for acute GVHD or death in the multivariate analysis.
|
9780337 |
1998 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
GeneticVariation |
BEFREE |
However, recipient incompatibility for DPB1 alleles does not detectably influence the risk of acute GVHD.
|
8461476 |
1993 |
|
HLA-DPB1
|
Acute GVH disease
|
0.100 |
Biomarker |
BEFREE |
HLA-DP and bone marrow transplantation: DP-incompatibility and severe acute graft versus host disease.
|
3326216 |
1987 |