A second ABC transporter, the hepatic phosphatidylcholine translocase ABCB4, increases the risk for gallstone disease, gallbladder cancer and chronic liver diseases in general, whereas the common PNPLA3 risk variant p.I148M decreases gallstone risk.
We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (rs738409" genes_norm="80339">p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1.
After adjustment for multiple testing, we detected a trend for an association between triglyceride levels and variant adiponutrin in gallstone patients (P=0.032), and gallstone cases carrying the genotype [CC] presented with significantly higher triglyceride levels than the corresponding controls (P<0.003).