Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 Biomarker BEFREE Preincubation of HNSCC supernatant leads to unrestorable reduction of IFN-α secretion in pDC and can not be restored by CpG 2216. 29456743

2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 Biomarker BEFREE 5-aza repressed expression and activity of matrix metalloproteinases (MMP) in HPV<sup>+</sup> HNSCC, activated IFN response in some HPV<sup>+</sup> head and neck cancer cells, and inhibited the ability of HPV<sup>+</sup> xenografted tumors to invade mouse blood vessels.<b>Conclusions:</b> 5-aza may provide effective therapy for HPV-associated HNSCC as an alternative or complement to standard cytotoxic therapy.<i></i>. 28916527

2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 Biomarker BEFREE Differential responsiveness of tumor cells to IFN-α and -β was further supported by the finding that autocrine IFN-β but not IFN-α promoted survival of HNSCC cells during persistent VSV infection. 25995245

2015
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 GeneticVariation BEFREE We demonstrate that LOH of 9p and, specifically, the interferon (IFN) gene cluster correlates with recurrence of HNSCC. 9484941

1998