Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 AlteredExpression BEFREE TTF-induced autophagy in GBM was associated with decreased Akt2 expression, not Akt1 or Akt3, via the mTOR/p70S6K pathway. 31375748

2019
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 Biomarker BEFREE We hypothesized that miR-641 regulates its host AKT2 and that this regulation may become dysfunctional in glioblastoma. 28576488

2017
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 AlteredExpression BEFREE There is a direct relationship between human GBM patient outcome and both AKT1 and AKT2 mRNA levels, but an inverse relationship with AKT3 mRNA. 27422127

2016
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 AlteredExpression BEFREE When combined with AEG-1 silencing, conditional expression of Akt2-PH markedly increased survival in an orthotopic mouse model of human GBM. 25304263

2014
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 Biomarker BEFREE Moreover, AKT2 is also exclusively required for the maintenance and survival of other PTEN-deficient solid tumors, including breast cancer and glioblastoma. 24838891

2014
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 Biomarker BEFREE In this study, the human glioblastoma cell line U87 was stably transfected with a lentivirus vector expressing a short hairpin RNA (shRNA) targeting AKT2. 22771706

2012
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 AlteredExpression BEFREE Additionally, immunohistochemical analysis showed that Akt2 expression positively correlates with Fn14 expression in glioblastoma multiforme specimens. 19861406

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 Biomarker BEFREE In vivo PTD-DRBD delivery of EGFR and Akt2 siRNAs induced tumor specific apoptosis and significantly increased survival in intracerebral glioblastoma mouse models (p < 0.0005), whereas delivery of irrelevant control siRNAs did not alter longevity. 19901546

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 AlteredExpression BEFREE Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. 9799739

1998