Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 Biomarker BEFREE It promotes GBM angiogenesis by inducing angiogenic factors such as vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI-I) and insulin- like growth factor-binding protein 7 (IGFBP7), contributes to GBM progression by inducing metalloproteinases (MMPs), "pro-neoplastic" integrins (αvβ3, α5β1) and GBM initiating cells (GICs) as well as inducing a GBM mesenchymal phenotype. 26514451

2015
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 AlteredExpression BEFREE Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways. 20467333

2010
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 Biomarker BEFREE Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. 20716639

2010
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 Biomarker BEFREE Bacterial O6-methylguanine-DNA methyltransferase reduces N-methyl-N'-nitro-N-nitrosoguanidine induction of plasminogen activator in Mer- human glioblastoma A1235 cell line. 9678063

1998
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 Biomarker BEFREE Transforming growth factor-beta 1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines. 3262361

1988
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 Biomarker BEFREE Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain. 3697974

1986