Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR BCR-ABL kinase domain mutations, including 2 novel mutations in imatinib resistant Malaysian chronic myeloid leukemia patients-Frequency and clinical outcome. 24456693

2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR [Correlation between point mutation in ABL kinase and clinical outcome of chronic myeloid leukemia patients]. 25152116

2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Early detection and quantification of mutations in the tyrosine kinase domain of chimerical BCR-ABL1 gene combining high-resolution melting analysis and mutant-allele specific quantitative polymerase chain reaction. 22870928

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib. 23676790

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Evaluation of T315I mutation frequency in chronic myeloid leukemia patients after imatinib resistance. 23540562

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Rapid Evolution to Blast Crisis Associated with a Q252H ABL1 Kinase Domain Mutation in e19a2 BCR-ABL1 Chronic Myeloid Leukaemia. 24109527

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Detection of ABL1 kinase mutations in Philadelphia-positive patients exhibiting an inadequate molecular response using restriction fragment mass polymorphism and its clinical significance: a single-center experience in Korea. 23575252

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study. 24236021

2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients. 23355941

2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile. 22210874

2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients. 22912393

2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations? 21221851

2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Rapid quantitative detection of the T315I mutation in patients with chronic myelogenous leukemia. 22306673

2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Rapid and sensitive allele-specific (AS)-RT-PCR assay for detection of T315I mutation in chronic myeloid leukemia patients treated with tyrosine-kinase inhibitors. 20512393

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia. 21895409

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Low-level Bcr-Abl mutations are very rare in chronic myeloid leukemia patients who are in major molecular response on first-line nilotinib. 21762985

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile. 21505103

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR F317L BCR-ABL1 kinase domain mutation associated with a sustained major molecular response in a CML patient on dasatinib. 21489624

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Analysis of ABL kinase domain mutations conferring resistance to tyrosine kinase inhibitors in chronic myeloid leukemia cases from India. 21888027

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors. 21872826

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Practical advice for determining the role of BCR-ABL mutations in guiding tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia. 21509757

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. 21562040

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation are resistant to dasatinib: is that true for all the patients? 21605905

2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.800 GeneticVariation CLINVAR Characteristics of BCR-ABL kinase domain point mutations in Chinese imatinib-resistant chronic myeloid leukemia patients. 20697894

2011