Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Anti-tumor activity of motesanib in a medullary thyroid cancer model. 21422803

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. 23056499

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. 20943719

2011
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. 18073307

2008
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 CausalMutation CLINVAR Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B. 17108110

2006
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor. 15753368

2005
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. 15184865

2004
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 CausalMutation CLINVAR The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. 15277225

2004
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome. 11351254

2001
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 CausalMutation CLINVAR Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma. 10445857

1999
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein. 10490816

1999
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan. 9839497

1998
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype. 9012462

1997
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain. 9242375

1997
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.700 GeneticVariation CLINVAR RET activation by germline MEN2A and MEN2B mutations. 8570194

1995