×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.
30152102
2018
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
29785153
2018
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Complexities of Variant Classification in Clinical Hereditary Cancer Genetic Testing.
28981386
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
27798748
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Efforts Toward Consensus Variant Interpretation by Commercial Laboratories.
28135139
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.
28495237
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women.
28727877
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Improving performance of multigene panels for genomic analysis of cancer predisposition.
26845104
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.
26898890
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
26534844
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.
27621404
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
25503501
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Use of panel tests in place of single gene tests in the cancer genetics clinic.
25318351
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
25503501
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.
24556621
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.
24506336
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
24763289
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
22419737
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
CausalMutation
CLINVAR
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
21244692
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
18571837
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
18706089
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
18085035
2007
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.
16551709
2006
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Breast and Ovarian Cancer Syndrome
0.460
GeneticVariation
CLINVAR
CHEK2-positive breast cancers in young Polish women.
16914568
2006