Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 GeneticVariation CLINVAR Phase II study of the GI-4000 KRAS vaccine after curative therapy in patients with stage I-III lung adenocarcinoma harboring a KRAS G12C, G12D, or G12V mutation. 25044103

2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. 24035431

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. 23524406

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. 22798288

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 GeneticVariation CLINVAR Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. 23014527

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. 22743296

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. 21483012

2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210

2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912

2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. 12460919

2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CLINVAR

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 GeneticVariation CLINVAR

Entrez Id: 5002
Gene Symbol: SLC22A18
SLC22A18
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.600 CausalMutation CLINVAR

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.500 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.500 GeneticVariation CLINVAR Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. 16043828

2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.500 CausalMutation CLINVAR

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.500 CausalMutation CLINVAR

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.500 CausalMutation CLINVAR