×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
Biomarker
GENOMICS_ENGLAND
Consensus for genes to be included on cancer panel tests offered by UK genetics services: guidelines of the UK Cancer Genetics Group.
29661970 2018
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.
30381462 2018
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
Biomarker
GENOMICS_ENGLAND
Consensus for genes to be included on cancer panel tests offered by UK genetics services: guidelines of the UK Cancer Genetics Group.
29661970 2018
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.
28825726 2017
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
GeneticVariation
UNIPROT
We identified the BRCA1 /2 genetic mutation test results of 1223 breast cancer patients and 174 patients with ovarian cancer.
28364669 2017
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Finally, we show that epigenetic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signature 3 and, in our data set, was highly enriched in basal-like breast cancers in young individuals of African descent.
28825726 2017
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Sox2-promoted Cre-expressing hemizygous males were mated with floxed brca1 females, and gestational day 8 +/- brca1 conditional knockout embryos with a 28% reduction in protein expression were exposed in culture to the reactive oxygen species (ROS)-initiating drug ethanol (EtOH).
26629949 2016
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Estrogen Receptor Alpha (ER) is expressed in about 70% of breast cancer and mediates various cellular signaling events including cell cycle.27580430 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Thus, we concluded that highly expressed HBXIP accelerates the MDM2-mediated degradation of p53 in breast cancer through modulating the feedback loop of MDM2/p53, resulting in the fast growth of breast cancer cells.
26229107 2015
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
These results validate the concept of using pigs as a model to study BRCA1 defects in breast cancer and establish the first porcine breast tumor cell line.
26379698 2015
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer .
26587011 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Genomic landscape of cutaneous T cell lymphoma.
26192916 2015
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
25330770 2014
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer.
25267515 2014
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Molecular profiling of single circulating tumor cells with diagnostic intention.
25358515 2014
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro.
24014025 2013
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Malignant neoplasm of breast
1.000
GeneticVariation
UNIPROT
Mutations in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian cancers, and therefore sequence analysis of both genes is routinely conducted in patients with early-onset breast cancer .
23867111 2013
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
GeneticVariation
UNIPROT
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
24013206 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer .24185512 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Taken together, these studies suggest that activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy.
24185510 2013
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
GeneticVariation
UNIPROT
The relevance of many BRCA2 variants of uncertain significance (VUS) to breast cancer has not been determined due to limited genetic information from families carrying these alterations.
23108138 2013
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
In this study, we report the development of a knock-in mouse model for breast cancer where the endogenous Pik3ca allele was modified to allow tissue-specific conditional expression of a frequently found Pik3ca (H1047R) (Pik3ca (e20H1047R)) mutant allele.
22370636 2013
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
Biomarker
GENOMICS_ENGLAND
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.
23788249 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.
22038807 2012
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of breast
1.000
Biomarker
CTD_human
Prevalence of BRCA mutations in an unselected population of triple-negative breast cancer.
22614657 2012