Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 Biomarker CTD_human Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259

2014
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 Biomarker CTD_human Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire. 17687452

2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 GeneticVariation UNIPROT

Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 CausalMutation CGI

Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_human Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_human Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259

2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046

2013
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046

2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_human More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine. 17979968

2008
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 GeneticVariation UNIPROT

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 CausalMutation CGI

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 CausalMutation CGI

Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 CausalMutation CGI

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.560 Biomarker CTD_human MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway. 27777383

2016
Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.560 CausalMutation CGI

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.500 Biomarker CTD_human Some of these EGFR-mutated PDXs do not respond to erlotinib: LU1868 containing L858R/T790M mutations, and LU0858 having L858R mutation as well as c-MET gene amplification, both squamous cell carcinoma (SCC). 22948846

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.500 Biomarker CTD_human EGFR-amplified tumors showed the highest fraction of squamous cell carcinoma (17%; n = 4 of 23). 22042947

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.500 Biomarker CTD_human Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells. 12942316

2003
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.500 CausalMutation CGI

Entrez Id: 51741
Gene Symbol: WWOX
WWOX
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.460 Biomarker CTD_human Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo. 17575124

2007
Entrez Id: 51151
Gene Symbol: SLC45A2
SLC45A2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.410 Biomarker CTD_human A melanoma- and pigmentation-associated variant in the SLC45A2 gene, L374F, is associated with risk of both BCC and squamous cell carcinoma. 19578363

2009
Entrez Id: 2017
Gene Symbol: CTTN
CTTN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker CTD_human In an animal model, cortactin is shown to upregulate in infiltrating squamous cell carcinoma, papilloma, and epithelia with squamous hyperplasia, indicating that cortactin induction is an early event during oral carcinogenesis. 27148699

2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker CTD_human The combination of ATO/PD173074 was studied in a proof-of-principle model using a lung SCC cell line with FGFR1 overexpression: SK-MES-1. 27794399

2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker CTD_human Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners. 26372664

2016
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker CTD_human PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling. 26432044

2015