Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET ERK1/2 mRNA expression was down-regulated in the depression model group compared with the normal control group (P<0.01). 21368416

2011
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. 20657013

2010
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Although ERK1/2 has been proposed as a common mediator of antidepressant action in naive rodents, it remains to be determined whether the ERK1/2 pathway plays a role in depressive disorder. 19424057

2009
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate. 17889834

2008
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Mice lacking ERK1 exhibited enhanced fear extinction and reduced depression caused by overactivation of ERK2. 17712345

2008