×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900
Biomarker
CTD_human
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
30224649 2018
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900
Biomarker
CTD_human
A single-nucleotide polymorphism (SNP) in the ptpn22 gene correlates with the incidence of various autoimmune diseases, including type 1 diabetes , rheumatoid arthritis, and systemic lupus erythematosus.
21190368 2011
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900
GeneticVariation
UNIPROT
We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22 ) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D ).
15004560 2004
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Therapeutic
CTD_human
Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia.
20620209 2010
×
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_human
×
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
CTD_human
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.
21340626 2011
×
Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
CTD_human
Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status.
16506275 2006
×
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
30224649 2018
HLA-DQB1
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
26168013 2015
HLA-DRB1
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
26168013 2015
HLA-DQA1
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
26168013 2015
×
Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model.
23499715 2013
×
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D .
19119414 2009
×
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Here we use polychromatic flow cytometry to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA , or CD25 ) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases, type 1 diabetes (T1D ) and multiple sclerosis.
19701192 2009
×
Entrez Id: 3586
Gene Symbol: IL10
IL10
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
19430480 2009
×
Entrez Id: 23274
Gene Symbol: CLEC16A
CLEC16A
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
18946483 2009
×
Entrez Id: 23274
Gene Symbol: CLEC16A
CLEC16A
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
17632545 2007
×
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
CTD_human
Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D .
17676041 2007
×
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 10019
Gene Symbol: SH2B3
SH2B3
Diabetes Mellitus, Insulin-Dependent
0.460
Biomarker
CTD_human
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
30224649 2018
×
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
Diabetes Mellitus, Insulin-Dependent
0.440
Biomarker
CTD_human
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
19430480 2009
×
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
Diabetes Mellitus, Insulin-Dependent
0.430
Biomarker
CTD_human
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
30224649 2018