Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 196
Gene Symbol: AHR
AHR
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.400 Biomarker CTD_human Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b. 30346592

2019
Entrez Id: 196
Gene Symbol: AHR
AHR
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.400 Biomarker CTD_human To test this hypothesis and determine whether the mouse Ahr gene acts as a tumor suppressor gene in vivo, we have examined the role of Ahr ablation in liver tumorigenesis induced by the genotoxic chemical diethylnitrosamine (DEN), a hepatic carcinogen that is not an AHR ligand.In mice given a single i.p. injection of DEN, AHR antagonized liver tumor formation and growth by regulating cell proliferation, inflammatory cytokine expression, and DNA damage, parameters which were significantly elevated in the livers of control and, more so, of DEN-exposed Ahr-/- mice. 19996281

2010