Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.800 Biomarker CTD_human The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. 23873848

2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.800 Biomarker CTD_human Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.800 GeneticVariation UNIPROT Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.800 Biomarker GENOMICS_ENGLAND Multiple hamartoma syndrome (Cowden's disease). 4635800

1972
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.800 CausalMutation CGI

Entrez Id: 3621
Gene Symbol: ING1
ING1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.710 GeneticVariation UNIPROT Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. 10866301

2000
Entrez Id: 3621
Gene Symbol: ING1
ING1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.710 Biomarker CTD_human

Entrez Id: 3621
Gene Symbol: ING1
ING1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.710 CausalMutation CGI

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human ΔNp63 promotes IGF1 signalling through IRS1 in squamous cell carcinoma. 30594912

2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. 26909611

2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542

2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human The TP53-3p interaction is specific to chromosome 3p and validates in HNSCC and pan-cancer cohorts. 25086664

2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 Biomarker CTD_human In this study, we evaluated the in vitro and in vivo efficacy of rigosertib in both HPV(+) and HPV(-) HNSCCs, focusing on inhibition of the PI3K pathway. 23873848

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.500 CausalMutation CGI

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 CausalMutation CGI

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human This was verified by IHC staining of CCND1 from HNSCC patients. 29464035

2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human Deletion of CDKN2A (p16) or amplification of CCND1 (cyclin D1) occurs commonly in head and neck squamous cell carcinoma (HNSCC) and induces sustained cyclin-dependent kinase (CDK) 4/6 activation. 26909611

2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human We found that HN3 and FaDu cells expressed strongly phosphorylated STAT3 on both tyrosine 705 and serine 727 residues as compared to other SCCHN cells. 27064016

2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. 23873848

2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. 12969226

2003
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 CausalMutation CGI

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 CausalMutation CGI

Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.390 Biomarker CTD_human Upregulation of cell cycle genes in head and neck cancer patients may be antagonized by erufosine's down regulation of cell cycle processes in OSCC cells. 29464035

2018
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.390 Biomarker CTD_human Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542

2014