Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN The interplay of CDK4 and CDK6 in melanoma. 30858922

2019
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN Familial risk of melanoma and links with other cancers. 30190834

2015
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. 23384855

2013
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation. 15880589

2005
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. 11756559

2002
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. 9425228

1998
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation UNIPROT Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. 9425228

1998
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation UNIPROT Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. 9311594

1997
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. 8528263

1996
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker GENOMICS_ENGLAND Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. 8528263

1996
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation UNIPROT Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. 8528263

1996
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation UNIPROT A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. 7652577

1995
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CLINGEN A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. 7652577

1995
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C1836892
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 		0.700 Biomarker CTD_human