Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis. 26694608

2016
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1. 24163136

2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Ligand binding and aggregation of pathogenic SOD1. 23612299

2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis. 24256636

2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Copper depletion increases the mitochondrial-associated SOD1 in neuronal cells. 21140194

2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study. 20485746

2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q. 19227972

2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Different immunoreactivity against monoclonal antibodies between wild-type and mutant copper/zinc superoxide dismutase linked to amyotrophic lateral sclerosis. 15522870

2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution. 16105836

2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. 15264227

2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Modification of cysteine 111 in Cu/Zn superoxide dismutase results in altered spectroscopic and biophysical properties. 15096637

2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754

2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. 12127151

2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178

2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis. 11675877

2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis. 11181815

2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Familial amyotrophic lateral sclerosis with a novel Leu126Ser mutation in the copper/zinc superoxide dismutase gene showing mild clinical features and lewy body-like hyaline inclusions. 11346368

2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. 10764647

2000
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker CTD_human Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. 8967745

1996