DisGeNET - a database of gene-disease associations

Source: GWASCAT

Disease: Lupus Erythematosus, Systemic ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

30573655

2019

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.

27193031

2017

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

27399966

2016

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

26502338

2015

Entrez Id:	26191
Gene Symbol:	PTPN22

PTPN22

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

19838195

2009

Entrez Id:	6775
Gene Symbol:	STAT4

STAT4

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

30573655

2019

Entrez Id:	10318
Gene Symbol:	TNIP1

TNIP1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

30573655

2019

Entrez Id:	3663
Gene Symbol:	IRF5

IRF5

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

30573655

2019

Entrez Id:	7128
Gene Symbol:	TNFAIP3

TNFAIP3

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	3586
Gene Symbol:	IL10

IL10

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	55024
Gene Symbol:	BANK1

BANK1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	10318
Gene Symbol:	TNIP1

TNIP1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	3663
Gene Symbol:	IRF5

IRF5

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	6775
Gene Symbol:	STAT4

STAT4

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	3684
Gene Symbol:	ITGAM

ITGAM

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

26663301

2016

Entrez Id:	640
Gene Symbol:	BLK

BLK

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

26663301

2016

Entrez Id:	7128
Gene Symbol:	TNFAIP3

TNFAIP3

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

26663301

2016

Entrez Id:	10318
Gene Symbol:	TNIP1

TNIP1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

26606652

2016

Entrez Id:	3684
Gene Symbol:	ITGAM

ITGAM

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

27399966

2016

Entrez Id:	3684
Gene Symbol:	ITGAM

ITGAM

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

26606652

2016

Entrez Id:	6775
Gene Symbol:	STAT4

STAT4

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

27399966

2016

Entrez Id:	6775
Gene Symbol:	STAT4

STAT4

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

26663301

2016

Entrez Id:	7128
Gene Symbol:	TNFAIP3

TNFAIP3

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

27399966

2016