Source: GWASCAT

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.500 GeneticVariation GWASCAT Ten of the likely effector genes, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11), have therapeutics approved or in clinical trials, with mechanisms of action supportive of evaluation for efficacy in osteoarthritis. 30664745

2019
Entrez Id: 1800
Gene Symbol: DPEP1
DPEP1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 8854
Gene Symbol: ALDH1A2
ALDH1A2
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 GeneticVariation GWASCAT Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. 24728293

2014
Entrez Id: 64116
Gene Symbol: SLC39A8
SLC39A8
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.160 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 84444
Gene Symbol: DOT1L
DOT1L
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.160 GeneticVariation GWASCAT Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. 22566624

2012
Entrez Id: 1301
Gene Symbol: COL11A1
COL11A1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.150 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.130 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.130 GeneticVariation GWASCAT Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. 29559693

2018
Entrez Id: 26354
Gene Symbol: GNL3
GNL3
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.130 GeneticVariation GWASCAT Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
Entrez Id: 23263
Gene Symbol: MCF2L
MCF2L
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.130 GeneticVariation GWASCAT A variant in MCF2L is associated with osteoarthritis. 21871595

2011
Entrez Id: 10466
Gene Symbol: COG5
COG5
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.120 GeneticVariation GWASCAT A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. 20112360

2010
Entrez Id: 55245
Gene Symbol: UQCC1
UQCC1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 4052
Gene Symbol: LTBP1
LTBP1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 150356
Gene Symbol: CHADL
CHADL
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. 28319091

2017
Entrez Id: 816
Gene Symbol: CAMK2B
CAMK2B
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. 23989986

2014
Entrez Id: 8464
Gene Symbol: SUPT3H
SUPT3H
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
Entrez Id: 11062
Gene Symbol: DUS4L
DUS4L
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.110 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. 21068099

2011
Entrez Id: 80274
Gene Symbol: SCUBE1
SCUBE1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 10198
Gene Symbol: MPHOSPH9
MPHOSPH9
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 1780
Gene Symbol: DYNC1I1
DYNC1I1
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 29945
Gene Symbol: ANAPC4
ANAPC4
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 55083
Gene Symbol: KIF26B
KIF26B
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
Entrez Id: 10180
Gene Symbol: RBM6
RBM6
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019