rs199474657
|
|
Impaired glucose tolerance
|
G |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
rs1801282
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014).
|
21877956 |
2012 |
rs1801282
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
|
17213274 |
2007 |
rs1801282
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
|
16804087 |
2006 |
rs1801282
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05).
|
10843155 |
2000 |
rs1805192
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014).
|
21877956 |
2012 |
rs1805192
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
|
17213274 |
2007 |
rs1805192
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
|
16804087 |
2006 |
rs1805192
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05).
|
10843155 |
2000 |
rs7903146
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs7903146 variant in the <i>TCF7L2</i> gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time.
|
28611053 |
2017 |
rs7903146
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype.
|
21399856 |
2011 |
rs7903146
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.
|
17593304 |
2007 |
rs7903146
|
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001).
|
16855264 |
2006 |
rs12255372
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians.
|
21399856 |
2011 |
rs12255372
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether the two most strongly associated variants (rs12255372 and rs7903146) predict the progression to diabetes in persons with impaired glucose tolerance who were enrolled in the Diabetes Prevention Program, in which lifestyle intervention or treatment with metformin was compared with placebo.
|
16855264 |
2006 |
rs12255372
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped four of the SNPs (rs7901695, rs7903146, rs11196205, and rs12255372) in Amish subjects with type 2 diabetes (n = 137), impaired glucose tolerance (IGT; n = 139), and normal glucose tolerance (NGT; n = 342).
|
16936218 |
2006 |
rs1232898090
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014).
|
21877956 |
2012 |
rs1232898090
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
rs1232898090
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
The association of the Pro12Ala polymorphism of the PPAR-gamma2 gene with the incidence of type 2 diabetes was investigated in 522 subjects with impaired glucose tolerance (IGT) participating in the Finnish Diabetes Prevention Study.
|
12145174 |
2002 |
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation.
|
8879960 |
1996 |
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance.
|
8931690 |
1996 |
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, the data do not support the suggested involvement of the Gly40Ser polymorphism in impaired glucose tolerance and the hypothesis of an association between NIDDM and the glucagon receptor gene in this population.
|
8690179 |
1995 |
rs5219
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
The KCNJ11 E23K and ABCC8 exon 31 variants contribute to susceptibility to T2D diabetes, glucose intolerance and altered insulin secretion in a Russian population.
|
18758683 |
2009 |
rs5219
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
We conclude that the lysine variant in KCNJ11 E23K leads to diminished insulin secretion in individuals with IGT.
|
17259403 |
2007 |
rs5219
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |