|
rs1137100
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
rs1137100
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
In premenopausal women with IGT</span> (n = 65), associations were found with Lys(109)Arg and Lys(656)Asn for overall glucose response to the glucose load.
|
11443193 |
2001 |
|
rs1137101
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
rs1137101
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
In postmenopausal women with IGT (n = 24), associations were found with Lys(109)Arg and Lys(656)Asn for fasting insulin (P = 0.05) and with Lys(109)Arg and Gln(223)Arg for the insulin response to an OGTT (P < 0.02).
|
11443193 |
2001 |
|
rs137852671
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin secretion due a failure of insulin content to increase with age.
|
23903354 |
2013 |
|
rs137852671
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data corroborate the hypothesis that the dominant E1506K ABCC8 mutation, responsible for CHI, predisposes to the development of glucose intolerance and diabetes later in life.
|
20042013 |
2010 |
|
rs1799945
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
C282Y/H63D compound heterozygous individuals who had glucose intolerance had more severe fibrosis compared with those without glucose intolerance (1.0+/-1.0 vs. 0.1+/-0.3, P=0.01).
|
16584391 |
2006 |
|
rs1799945
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes.
|
12148086 |
2002 |
|
rs1805097
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
These data indicate that IRS2 is an influential gene in severe obesity and glucose intolerance in this population, whereas gene-based haplotypes of IRS2 have revealed heterogeneity in the behaviour of the Gly1057Asp mutation in relation to insulin resistance.
|
12687350 |
2003 |
|
rs1805097
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Gly1057Asp polymorphism was not associated with insulin resistance or impaired insulin secretion in Finnish subjects with normal glucose tolerance (n = 295) or impaired glucose tolerance (n = 38).
|
11473060 |
2001 |
|
rs4402960
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
rs4402960
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
The analyses showed that age (P < 0.0001), BMI (P < 0.0001), and six variants (IGF2BP2 rs4402960, P = 0.002; ADIPOQ+276 G>T, P = 0.004; UCP2Ala55Val, P = 0.01; CDKN2AI2B rs3731201, P = 0.02; rs495490, P = 0.02, and rsl 0811661, P = 0.03) were significantly associated with the risk of IFG/IGT/T2DM.
|
20384434 |
2010 |
|
rs560887
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Glucose tolerance status and genotype interacted on insulin secretion (P=0.036), such that in NGT subjects, the minor A-allele of rs560887 was associated with decreased insulinogenic index (P=0.044), which was not the case in subjects with IFG/IGT (P=1.0).
|
20826583 |
2010 |
|
rs560887
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
|
19669124 |
2009 |
|
rs8192678
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Gly482Ser SNPs was detected by PCR-RFLP in a cohort of 358 Caucasian obese subjects (223 with normal glucose tolerance (NGT) and 125 with impaired glucose tolerance (IGT).
|
16403952 |
2005 |
|
rs8192678
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
rs1042714
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that the beta(2)-AR gene (Gln27Glu) variant might not be an important factor for obesity or IGT in Japanese subjects.
|
11288039 |
2001 |
|
rs1049673
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The major findings of this study were that rs1049673 was found associated with IFG/IGT and T2D in essential hypertension patients (Pco = 0.028; Pdom = 0.015).
|
22869067 |
2012 |
|
rs10811661
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data, together with the meta-analysis of previously published studies, show that the rs10811661 polymorphism is associated with impaired insulin release and IGT, suggesting that this variant may contribute to type 2 diabetes by affecting beta cell function.
|
21234743 |
2011 |
|
rs10830963
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a state of i-IFG and not through i-IGT.
|
19324940 |
2009 |
|
rs11061946
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the individuals homozygous for the rare minor alleles of rs11061946 and rs11061973 had increased risk of converting from IGT to T2DM.
|
21943112 |
2011 |
|
rs11061973
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the individuals homozygous for the rare minor alleles of rs11061946 and rs11061973 had increased risk of converting from IGT to T2DM.
|
21943112 |
2011 |
|
rs1111875
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
rs11136000
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs1169288
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |