|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.
|
26485766 |
2015 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
Correlation between protein kinase catalytic subunit alpha-1 gene rs13361707 polymorphism and gastric cancer susceptibility in asian populations.
|
28978122 |
2017 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In the dominant model, SNPs rs13361707 [odds ratio (OR) = 1.51, 95%CI: 1.07-2.11)], rs154268 (OR = 1.65, 95%CI: 1.22-2.22), rs6882903 (OR = 1.48, 95%CI: 1.09-2.00), and rs10074991 (OR = 1.53, 95%CI: 1.09-2.16) were significantly associated with an increased risk of gastric cancer.
|
25024613 |
2014 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In similar, an increased risk of gastric cancer was also observed for rs13361707</span> TC genotype (adjusted OR = 1.47, 95%CI: 1.01-2.14, p = 0.043; additive model: adjusted OR = 1.22, 95%CI: 1.02-1.47, p = 0.033).
|
30253744 |
2018 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population.
|
23861218 |
2013 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
rs13361707
|
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk.
|
29620653 |
2018 |
|
rs9841504
|
|
Malignant neoplasm of stomach
|
|
0.720 |
GeneticVariation
|
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
|
rs9841504
|
|
Malignant neoplasm of stomach
|
|
0.720 |
GeneticVariation
|
BEFREE |
However, we found no association between rs9841504 and gastric cancer risk.
|
23861218 |
2013 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer.
|
27525907 |
2016 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analysis by country revealed that the rs2275913 G>A and rs763780 T>C polymorphisms may be the main risk factor for gastric cancer in Chinese and Japanese populations.
|
25987798 |
2015 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.
|
25338988 |
2014 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the IL-17A rs3748067C>T and IL-17F rs763780 T>C polymorphisms play an important role in the risk of gastric cancer in a Chinese population.
|
26535650 |
2015 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analysis showed that rs2275913 GG (OR = 1.35, 95%CI = 1.05-1.73) and rs763780 TC (OR= 1.44, 95%CI = 1.20-1.75) genotypes were not significantly associated with increased risk of gastric cancer in Japanese populations.
|
26125910 |
2015 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, IL-17A rs2275913 A/G polymorphism and IL-17F rs763780 C/T polymorphism might be associated with increased GC risk in Asians.
|
25500254 |
2015 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2275913G>A and rs763780T>C polymorphisms increase gastric cancer risk, and interact with H. pylori infection and subsites.
|
24218334 |
2014 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.
|
29860554 |
2018 |
|
rs763780
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively.
|
25374195 |
2014 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current meta-analysis demonstrated that the XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations.
|
29049208 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we observed strong correlation between rs751402 polymorphism and gastric cancer (C vs T: OR=1.21, 95% CI = 1.00-1.26, P = .045; TC vs CC: OR = 1.12, 95% CI = 1.00-1.24, P = .041; TC/TT vs CC: OR = 1.13, 95% CI = 1.02-1.26, P = .020).
|
28796034 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations.
|
28832189 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population.
|
27323158 |
2016 |