|
rs10004195
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
rs10022537
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped four selected, potentially functional CD133 SNPs (rs2240688A>C, rs7686732C>G, rs10022537T>A, and rs3130C>T) and used logistic regression analysis for associations of these SNPs with GC risk and Cox hazards regression analysis for survival.
|
24302553 |
2015 |
|
rs10052016
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
After combining these two studies, we found that the G allele of rs10052016 (at 132 kb upstream of TERT) was significantly associated with a decreased risk of gastric cancer (OR = 0.76, 95% CI = 0.67-0.87, P = 5.35 × 10(-5)).
|
23901064 |
2013 |
|
rs10052657
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk.
|
30202044 |
2018 |
|
rs10088390
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, haplotype analysis showed that the A rs1127379 G rs10088390 haplotype conferred a risk effect for gastric cancer.
|
27739564 |
2017 |
|
rs1011445550
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population.
|
21161671 |
2011 |
|
rs10116253
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals carrying CC genotype of rs10116253 and TT genotype of rs1927911 had a significantly decreased risk of GC (adjusted OR=0.33, 95% CI 0.18-0.60, P<0.001 and adjusted OR=0.37, 95% CI 0.21-0.67, P=0.001 respectively), compared with TT genotype of rs10116253 and CC genotype of rs1927911.
|
24365597 |
2014 |
|
rs1016343
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results.
|
31288430 |
2019 |
|
rs1042028
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The prognostic significance of the SULT1A1 Arg213His polymorphism with respect to staging, differentiation and histological type of gastric cancer was also evaluated.
|
16137826 |
2005 |
|
rs10421916
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
INSL3 rs10421916 and rs11088680 had both a 0.8-fold decreased OR for gastric cancer (95% CIs = 0.7-0.97; and 0.7-0.9, respectively).
|
23028900 |
2012 |
|
rs1042229
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygous K alleles of rs1042229 were associated with stomach cancer (Odds ratio [OR]=1.62, confidence interval [CI]=1.05-2.48, p=0.028).
|
21216225 |
2011 |
|
rs10434
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G1612A(rs10434) and C936T(rs3025039) polymorphisms in the 3' untranslated region (3'-UTR) of VEGF gene were genotyped in a total of 844 subjects including 385 GC, 143 ulcer including 98 gastric ulcer (GU), 45 duodenal ulcer (DU), and 316 nonulcer subjects.
|
19496079 |
2009 |
|
rs1044432
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the nine SNPs, rs11133399 in CLOCK, rs1044432 and rs2279284 in BAML1 were significantly associated with GC overall survival and recurrence-free survival.
|
30843665 |
2019 |
|
rs1045411
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prognostic Significance of Tag SNP rs1045411 in HMGB1 of the Aggressive Gastric Cancer in a Chinese Population.
|
27116470 |
2016 |
|
rs10464867
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs10464867 (G>A) was significantly associated with a decreased risk of gastric cancer (odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.71-0.94; P = 4.71×10-3).
|
26402912 |
2015 |
|
rs10474606
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, individuals carrying the THBS4 rs10474606 variant homozygous AA had a modest reduced GC risk.
|
27160021 |
2016 |
|
rs1047840
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele Exol K589E conferred a significant (P = 0.0094) increased risk of gastric cancer.
|
20337148 |
2009 |
|
rs1048369
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were significant differences in both the genotype and allelic frequency of GPC4 gene (rs1048369) between the EBVaGC and EBVnGC patients.
|
27071854 |
2016 |
|
rs10484761
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population.
|
24325909 |
2014 |
|
rs1050450
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore evaluated the risk of TT genotype in GPX-1 C599T polymorphism with the onset of gastric cancer (P=0.0001; OR=5.41, 95% CI 1.98 to 15.58) and colorectal cancer (P=0.00008; OR=4.40, 95% CI 1.93 to 10.27).
|
27823653 |
2016 |
|
rs10509670
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs10511729
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
ASSET analyses identified four SNPs significantly associated with multiple cancers: rs3731239 (CDKN2A intronic) with ESCC, GC and BC (P = 3.96 × 10(-) (4)); rs10811474 (3' of IFNW1) with RCC and BrC (P = 0.001); rs12683422 (LINGO2 intronic) with RCC and BC (P = 5.93 × 10(-) (4)) and rs10511729 (3' of ELAVL2) with LC and BrC (P = 8.63 × 10(-) (4)).
|
25239644 |
2014 |
|
rs1051690
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>INSR</i> rs1051690 SNP is associated with increased risk of GC, while polymorphisms in <i>IL12B</i>, <i>CCND1</i> and <i>IL10</i> genes are not linked with the presence of GC.
|
28596683 |
2017 |
|
rs1051740
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT.
|
17164366 |
2006 |
|
rs1053023
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
There is a strong link between pri-miR-124-1 rs531564 and STAT3 rs1053023 and gastric cancer that may be pathogenic, and so worthy of further investigation.
|
29938592 |
2018 |