|
rs1126647
|
|
Mental disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped three single nucleotide polymorphisms (SNPs) within IL-8 gene (rs4073, rs2227306 and rs1126647) in 229 individuals who attempted suicide with soft suicide methods, 235 suicide victims and 290 individuals without any history of psychiatric disorders or suicide attempt.
|
30099207 |
2018 |
|
rs1126647
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs112</span>6647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs1126647
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk for hypertension was increased in the presence of the T allele in IL8 rs1126647 (OR = 1.69, 95 % CI = 1.07-2.67, P = 0.024).
|
26387812 |
2015 |
|
rs1126647
|
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The male population carrying the homozygote TT genotype and T allele of rs4073, the homozygote CC genotype and C allele of rs2227306 and homozygote AA genotype and A allele of rs1126647 are more susceptible to sepsis, suggesting there is a protective effect in females carrying these genotypes and alleles respectively.
|
27642120 |
2016 |
|
rs1126647
|
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped three single nucleotide polymorphisms (SNPs) within IL-8 gene (rs4073, rs2227306 and rs1126647) in 229 individuals who attempted suicide with soft suicide methods, 235 suicide victims and 290 individuals without any history of psychiatric disorders or suicide attempt.
|
30099207 |
2018 |
|
rs1126647
|
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The male population carrying the homozygote TT genotype and T allele of rs4073, the homozygote CC genotype and C allele of rs2227306 and homozygote AA genotype and A allele of rs1126647 are more susceptible to sepsis, suggesting there is a protective effect in females carrying these genotypes and alleles respectively.
|
27642120 |
2016 |
|
rs1126647
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs112</span>6647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs1126647
|
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs112</span>6647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs2227306
|
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data showed that the expression level of IL-8 was associated with the development of GD, and the C-allele frequency of SNP rs2227306 was significantly higher in GD and GO patients compared with healthy controls.
|
19816813 |
2009 |
|
rs2227306
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of IL8-251 A/T (rs4073) and + 781C/T (rs2227306) polymorphisms was significantly associated with an increased risk of asthma (P = 0.002, P = 0.036, respectively).
|
28993876 |
2017 |
|
rs2227306
|
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs1126647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs2227306
|
|
Lung diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The severity of lung disease was associated with the following markers: transcutaneous arterial hemoglobin oxygen saturation (SaO2) (regardless of CFTR genotype, for the polymorphisms rs4073, rs2227306 and rs2227307); mucoid Pseudomonas aeruginosa (regardless of CFTR genotype, for the polymorphisms rs2227306 and rs2227307).
|
27209008 |
2016 |
|
rs2227306
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs1126647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs2227306
|
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the current study was to examine the influence of the IL-8 gene polymorphisms at positions -251 (rs4073) and +781 (rs2227306) on the risk of osteoarthritis.
|
25194757 |
2014 |
|
rs2227306
|
|
Cystic Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identified the IL8 gene, represented by rs4073 and rs2227306 polymorphisms, and particularly the rs2227307 polymorphism, as potentiating factors for the degree of variability in the severity of CF, especially in pulmonary clinical manifestation correlated with increased morbidity and mortality.
|
27209008 |
2016 |
|
rs2227306
|
|
Arthritis, Gouty
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, we observed no significant relationship between the IL-8 rs2227306 polymorphism and primary gouty arthritis risk.
|
27813564 |
2016 |
|
rs2227306
|
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The male population carrying the homozygote TT genotype and T allele of rs4073, the homozygote CC genotype and C allele of rs22</span>27306 and homozygote AA genotype and A allele of rs1126647 are more susceptible to sepsis, suggesting there is a protective effect in females carrying these genotypes and alleles respectively.
|
27642120 |
2016 |
|
rs2227306
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two IL8 SNPs (rs4073A/T, rs2227306C/T) and three SNPs tagging CXCR1 and CXCR2 (rs4674258C/T, rs1008563C/T, rs6723449T/C) were analyzed for association with IL8 levels and with MI risk.
|
24462138 |
2014 |
|
rs2227306
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs1126647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
|
rs2227306
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls.
|
21649933 |
2011 |
|
rs2227306
|
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
rs2227306
|
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotyping data from 192 patients with childhood IgAN and 397 controls showed significant differences in the frequencies of the CXCL8 gene with rs2227306 (dominant, P = 0.019; overdominant, P = 0.009), rs2227543 (dominant, P = 0.01; overdominant, P = 0.0057), and rs4073 (codominant, P = 0.034; dominant, P = 0.011; overdominant, P = 0.022).
|
21214373 |
2011 |
|
rs2227306
|
|
Lichen Planus, Oral
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs of the IL-8 gene at positions -845 T/C (rs2227532), -738 T/A, -251 A/T (rs4073) and +781 C/T (rs2227306) were analyzed in 109 patients with OLP and 101 normal controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
|
19842025 |
2010 |
|
rs2227306
|
|
Malignant neoplasm of liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
rs2227306
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we determined that there is a lack of evidence suggesting a significant association between the IL-8 rs4073 and rs2227306 gene polymorphisms and the development of glioma in a Chinese population.
|
27706570 |
2016 |